This was supposed to be Jack Johnson�s somber and
Thursday 4 September 2008
Monday 25 August 2008
Alternative Vaccine Strategy Shows Promise In Prostate Cancer Patients
�New research indicates that giving patients a continuous low lucy in the sky with diamonds of an immune system booster, a method known as metronomic dosing, as part of a healing prostate cancer vaccine strategy is safe and produces similar immune responses and fewer side of meat effects than the more than common dosing method, which is non well tolerated by many patients. This study, lED by researchers at that National Cancer Institute (NCI), part of the National Institutes of Health, was published in the Aug. 15, 2008, issue of Clinical Cancer Research.
The vaccine put-upon in this study is designed to stimulate an immune response against prostate-specific antigen (PSA), a protein produced by the prostate that is often establish at elevated levels in the blood of workforce who have prostate cancer and some non-cancerous prostate conditions. In the subject area, researchers examined the side effects and immune responses of patients treated with a three-pronged approach: the vaccine, radiation therapy, and an alternative dosing regimen of an immune system booster, interleukin-2 (IL-2). The patients all had localized prostate cancer the Crab, had not undergone surgery to remove the prostate, and were candidates for radiation therapy as their primary form of treatment.
"Developing an alternative method of administering vaccine therapy that is well tolerated by most patients and produces similar immune responses to standard methods crataegus oxycantha help farther the development of vaccine therapies for prostate cancer the Crab," said James L. Gulley, M.D., Ph.D., of NCI's Center for Cancer Research.
Therapeutic cancer vaccines ar designed to treat cancer by stimulating the immune system to attack tumor cells without harming normal cells. Several proteins, including PSA, are overexpressed, or produced in excess amounts, by cancer cells and have shown potential to serve as triggers in initiating immune responses. These findings have led to the exploitation of malignant neoplastic disease vaccines that target these proteins. The proteins ar also known as tumor-associated antigens. To heighten the body's natural defenses, immune system boosters, such as IL-2, ar often tending with the vaccines. IL-2 administration, however, is oftentimes associated with substantial face effects, including fatigue and high line sugar.
In a premature study involving the same prostate cancer vaccine, IL-2 was granted to 19 patients daily for cinque days during each 28-day vaccine intervention cycle, and a tumid majority of the patients had to have the dose of IL-2 reduced or discontinued, primarily because of fatigue.
In this new bailiwick, the researchers sought to decrease the side personal effects associated with IL-2. To do this, the squad treated 18 patients with the vaccinum and radiation syndrome therapy, just with depress doses of IL-2 apt over a longer period of time. The patients received the same amount amount of IL-2 as in the previous sketch, but it was administered in smaller daily doses for 14 days of each 28-day treatment hz.
With metronomic dosing, less than a quarter of the patients had side of meat effects that required their dose of IL-2 to be reduced.
The research team also found that metronomic dosing of IL-2 produced personal effects on immune cell populations and immune responses that were standardised to those observed previously with the standard dosing method. Five of eight evaluated patients had at least a three-fold gain in immune cells that were directed against PSA. The researchers also noted that, similar to the standard dosing method, metronomic dosing of IL-2 induced immune responses against early prostate cancer antigens in some patients.
"Based on safety and feasibility, metronomic dosing appears to be superior to standard dosing and governance," said Gulley. "More research is needed to measure the efficaciousness of this dosing method in treating prostate malignant neoplastic disease."
For more than information on Dr. Gulley's research, please go here.
For more information about cancer, please visit the NCI site at hTTP://www.cancer.gov, or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).
The National Institutes of Health (NIH) - The Nation's Medical Research Agency - includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal government agency for conducting and encouraging basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information virtually NIH and its programs, visit hypertext transfer protocol://www.national Institutes of Health.gov.
Reference
Lechleider RJ, Arlen PM, Tsang K, Steinberg SM, Yokokawa J, Cereda V, Camphausen K, Schlom J, Dahut WL, and Gulley JL. Safety and immunologic response of a viral vaccinum to PSA in combination with radiation therapy when metronomic-dose IL-2 is used as an adjuvant. Clinical Cancer Research. August 15, 2008.
Gulley JL, Arlen PM, Bastian A, Morin S, Marte J, Beetham P, Tsang K, Yokokawa J, Hodge JW, Menard C, Camphausen K, Coleman CN, Sullivan F, Steinberg SM, Schlom J, and Dahut W. Combining a recombinant cancer vaccine with standard unequivocal radiotherapy in patients with localized prostate cancer. Clinical Cancer Research. 2005;11:3353-62.
http://www.nih.gov
More info
The vaccine put-upon in this study is designed to stimulate an immune response against prostate-specific antigen (PSA), a protein produced by the prostate that is often establish at elevated levels in the blood of workforce who have prostate cancer and some non-cancerous prostate conditions. In the subject area, researchers examined the side effects and immune responses of patients treated with a three-pronged approach: the vaccine, radiation therapy, and an alternative dosing regimen of an immune system booster, interleukin-2 (IL-2). The patients all had localized prostate cancer the Crab, had not undergone surgery to remove the prostate, and were candidates for radiation therapy as their primary form of treatment.
"Developing an alternative method of administering vaccine therapy that is well tolerated by most patients and produces similar immune responses to standard methods crataegus oxycantha help farther the development of vaccine therapies for prostate cancer the Crab," said James L. Gulley, M.D., Ph.D., of NCI's Center for Cancer Research.
Therapeutic cancer vaccines ar designed to treat cancer by stimulating the immune system to attack tumor cells without harming normal cells. Several proteins, including PSA, are overexpressed, or produced in excess amounts, by cancer cells and have shown potential to serve as triggers in initiating immune responses. These findings have led to the exploitation of malignant neoplastic disease vaccines that target these proteins. The proteins ar also known as tumor-associated antigens. To heighten the body's natural defenses, immune system boosters, such as IL-2, ar often tending with the vaccines. IL-2 administration, however, is oftentimes associated with substantial face effects, including fatigue and high line sugar.
In a premature study involving the same prostate cancer vaccine, IL-2 was granted to 19 patients daily for cinque days during each 28-day vaccine intervention cycle, and a tumid majority of the patients had to have the dose of IL-2 reduced or discontinued, primarily because of fatigue.
In this new bailiwick, the researchers sought to decrease the side personal effects associated with IL-2. To do this, the squad treated 18 patients with the vaccinum and radiation syndrome therapy, just with depress doses of IL-2 apt over a longer period of time. The patients received the same amount amount of IL-2 as in the previous sketch, but it was administered in smaller daily doses for 14 days of each 28-day treatment hz.
With metronomic dosing, less than a quarter of the patients had side of meat effects that required their dose of IL-2 to be reduced.
The research team also found that metronomic dosing of IL-2 produced personal effects on immune cell populations and immune responses that were standardised to those observed previously with the standard dosing method. Five of eight evaluated patients had at least a three-fold gain in immune cells that were directed against PSA. The researchers also noted that, similar to the standard dosing method, metronomic dosing of IL-2 induced immune responses against early prostate cancer antigens in some patients.
"Based on safety and feasibility, metronomic dosing appears to be superior to standard dosing and governance," said Gulley. "More research is needed to measure the efficaciousness of this dosing method in treating prostate malignant neoplastic disease."
For more than information on Dr. Gulley's research, please go here.
For more information about cancer, please visit the NCI site at hTTP://www.cancer.gov, or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).
The National Institutes of Health (NIH) - The Nation's Medical Research Agency - includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal government agency for conducting and encouraging basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information virtually NIH and its programs, visit hypertext transfer protocol://www.national Institutes of Health.gov.
Reference
Lechleider RJ, Arlen PM, Tsang K, Steinberg SM, Yokokawa J, Cereda V, Camphausen K, Schlom J, Dahut WL, and Gulley JL. Safety and immunologic response of a viral vaccinum to PSA in combination with radiation therapy when metronomic-dose IL-2 is used as an adjuvant. Clinical Cancer Research. August 15, 2008.
Gulley JL, Arlen PM, Bastian A, Morin S, Marte J, Beetham P, Tsang K, Yokokawa J, Hodge JW, Menard C, Camphausen K, Coleman CN, Sullivan F, Steinberg SM, Schlom J, and Dahut W. Combining a recombinant cancer vaccine with standard unequivocal radiotherapy in patients with localized prostate cancer. Clinical Cancer Research. 2005;11:3353-62.
http://www.nih.gov
More info
Thursday 7 August 2008
Lotus Eaters
Artist: Lotus Eaters
Genre(s):
Ambient
Discography:
Mind Control for Infants
Year: 2002
Tracks: 6
Four Demonstrations 07.01
Year: 2001
Tracks: 4
Alienist On A Pale Horse Vinyl
Year: 2001
Tracks: 4
Liverpool, England's the Lotus Eaters were mistakenly included in the New Romantic drift when they number one appeared. However, although Peter Coyle (vocals), Jeremy Kelly (
Friday 27 June 2008
Moody hues at Playboy Jazz Festival
30th anniversary fest set for this weekend
If jazz had a Mount Rushmore, James Moody's face would be right up there with Charlie Parker and Dizzy Gillespie.
Maybe the next best thing -- aside from his live performance Saturday at the Playboy Jazz Festival -- is YouTube, where you can catch the great saxophonist as a member of Dizzy's first big band, back in the 1940s.
"If I'd have known what it was, I probably would have fainted with all that stuff," Moody likes to say of his stint with the source of the 20th century's greatest musical revolution.
" 'Cause when I joined the band, (Thelonious) Monk was the piano player and Klook was the drummer -- Kenny Clarke -- and Bags (Milt Jackson) was there, too." Not to mention such original gangsters as Miles Davis, Ray Brown and John Lewis.
Moody, 83, speaks today as he did when he was first recorded 60 years ago on the big band's "Emanon." This was not a health food store but a screaming blues track with breathtaking sarcastic breaks from Gillespie's horn, an inexorable groove from Ray Brown, the bassist, and a climactic passage reserved for Moody after Dizzy finishes.
Patrons of the 30th anniversary Playboy Jazz Festival will feel Moody's undiminished power when he appears with Roy Hargrove at the Hollywood Bowl. They can compare his live performance with the "Emanon" track, 99 cents on iTunes. The witty, emblematic opening; the bottomless resources; the unflagging swing; and the discreetly blasting climax -- his whole thing is there, and it has never run down.
On Saturday, Moody might favor MC Bill Cosby, his longtime friend, with a performance of the immortal "Moody's Mood for Love." He enthralled a Bowl audience last year when he and Roberta Gambarini combined the classic hit number with a deft comic routine.
Does he enjoy doing such things?
"Well, it depends," he said. "I enjoy playing music. I like to play music first, I mean that's what it is.
"I don't even like the comedy bit thing put in there because I'm really a musician. That's what I wanna do."
Does he feel that the long-popular number has overshadowed his other work?
"Well, I did that in 1949 in Stockholm, Sweden. That is when I did that." He would say no more on the topic.
So what would he and Hargrove play on Saturday?
"We'll play music," said the great James Moody, who is really a musician.
If jazz had a Mount Rushmore, James Moody's face would be right up there with Charlie Parker and Dizzy Gillespie.
Maybe the next best thing -- aside from his live performance Saturday at the Playboy Jazz Festival -- is YouTube, where you can catch the great saxophonist as a member of Dizzy's first big band, back in the 1940s.
"If I'd have known what it was, I probably would have fainted with all that stuff," Moody likes to say of his stint with the source of the 20th century's greatest musical revolution.
" 'Cause when I joined the band, (Thelonious) Monk was the piano player and Klook was the drummer -- Kenny Clarke -- and Bags (Milt Jackson) was there, too." Not to mention such original gangsters as Miles Davis, Ray Brown and John Lewis.
Moody, 83, speaks today as he did when he was first recorded 60 years ago on the big band's "Emanon." This was not a health food store but a screaming blues track with breathtaking sarcastic breaks from Gillespie's horn, an inexorable groove from Ray Brown, the bassist, and a climactic passage reserved for Moody after Dizzy finishes.
Patrons of the 30th anniversary Playboy Jazz Festival will feel Moody's undiminished power when he appears with Roy Hargrove at the Hollywood Bowl. They can compare his live performance with the "Emanon" track, 99 cents on iTunes. The witty, emblematic opening; the bottomless resources; the unflagging swing; and the discreetly blasting climax -- his whole thing is there, and it has never run down.
On Saturday, Moody might favor MC Bill Cosby, his longtime friend, with a performance of the immortal "Moody's Mood for Love." He enthralled a Bowl audience last year when he and Roberta Gambarini combined the classic hit number with a deft comic routine.
Does he enjoy doing such things?
"Well, it depends," he said. "I enjoy playing music. I like to play music first, I mean that's what it is.
"I don't even like the comedy bit thing put in there because I'm really a musician. That's what I wanna do."
Does he feel that the long-popular number has overshadowed his other work?
"Well, I did that in 1949 in Stockholm, Sweden. That is when I did that." He would say no more on the topic.
So what would he and Hargrove play on Saturday?
"We'll play music," said the great James Moody, who is really a musician.
Monday 23 June 2008
Kooks: 'Arctics are dead in the US'
The Kooks frontman Luke Pritchard has continued his war of words with the Arctic Monkeys by declaring their US career "dead".
Pritchard, who allegedly kicked Arctics frontman Alex Turner in the face, said the Kooks will be more successful in the US than their rivals.
He told The Sun: "It's really going great over there [in the US]. Radio is really picking up on the album.
"Arctic Monkeys have just died over there. They were huge for their first album but it hasn't happened with the second one."
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Pritchard, who allegedly kicked Arctics frontman Alex Turner in the face, said the Kooks will be more successful in the US than their rivals.
He told The Sun: "It's really going great over there [in the US]. Radio is really picking up on the album.
"Arctic Monkeys have just died over there. They were huge for their first album but it hasn't happened with the second one."
See Also
Sunday 15 June 2008
Panteon Rococo
Artist: Panteon Rococo
Genre(s):
Latin
Discography:
Companeros
Year:
Tracks: 15
A La Izquierda De La Tierra
Year:
Tracks: 14
Latin rock band from Mexico Panteón Rococó was formed in the mid-'90s, transcription its first EP, called Pa' Mi Negra, in 1997. The undermentioned year, the group participated in a double-album called Eskuela De Baile, tributary with two of its original songs, "L'America" and "Curame." A alike compiling called Puro Eskañol came a year later, including Panteón Rococó's "Borracho." In 1999, the ten-piece Latin ska and reggae band was awarded at an event known as Skalaria for being the Best Local Ska Performer. In October of that same year, Panteón Rococó released its debut album, A La Izquierda De La Tierra.
Wednesday 11 June 2008
The Headhunters
Artist: The Headhunters
Genre(s):
Other
Discography:
Return of the Headhunters!
Year: 2005
Tracks: 10
Double success for Take That at the Brits
Jolie Finds Childbirth 'Fascinating'
Angelina Jolie loves every aspect of motherhood - even hailing giving birth by Caesarean section "fascinating". The 32-year-old mother of four - who is currently expecting twins with partner Brad Pitt - insists childbirth is such a life-changing experience for her, it outweighs any pain she may feel during the process. Jolie gave birth to daughter Shiloh, now two, via Caesarean and she is looking forward to welcoming her unborn babies into the world this summer . She tells the new edition of Vanity Fair magazine, "I had a C-section (with Shiloh) and I found it fascinating. I didn't find it a sacrifice and I didn't find it a painful experience. "I found it a fascinating miracle of what a body can do." Jolie and Pitt are also parents to adopted kids Maddox, six, Pax, four, and Zahara, three.
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See Also
Erykah Badu tours 'Amerykah'
Neo-soul singer Erykah Badu has mapped out a six-week North American tour to support her latest release, "New Amerykah, Pt. One: 4th World War."
The Roots will join Badu on the majority of the outing, which is set to launch May 4 in Detroit. The performers will visit US cities from coast to coast, as well as a few Canadian provinces, and Badu will veer off for gigs in Puerto Rico and the Caribbean island of Aruba. Details are listed below.
After a lengthy hiatus from recording, Badu got back to business with her fourth studio set, "New Amerykah," which dropped on her 37th birthday in February and landed at No. 2 on The Billboard 200. The album's lead single, "Honey," was released late last year to coincide with the singer's 10-year anniversary in the music biz, and it's still making waves on R&B/hip-hop charts.
The new record marks Badu's first full-length in seven years. Her previous studio effort was 2003's gold-certified EP "Worldwide Underground," which also debuted in the Top 5 on The Billboard 200.
The four-time Grammy winner picked up her first couple of gold statues for her 1997 debut, "Baduizm," which has achieved multi-platinum status.
When she's not making music, Badu has a second career as an actress. She's appeared in films including "Blues Brothers 2000" and "Cider House Rules."
The Dallas-based songstress is also a humanitarian: She serves as a spokesperson for the AIDS Arms LifeWalk and she formed the nonprofit group B.L.I.N.D. (Beautiful Love Incorporated Non Profit Development), which works to create social change through economic, artistic and cultural development.
See Also
Ferry Corsten
Artist: Ferry Corsten
Genre(s):
Trance
Other
Discography:
Revive More Sleepless Nights EP
Year: 2007
Tracks: 8
Passport United States Of America
Year: 2007
Tracks: 15
Live at Dance Tour
Year: 2007
Tracks: 1
Beautiful (Dancetour Anthem 2007) CDS
Year: 2007
Tracks: 2
Sensation White
Year: 2006
Tracks: 1
Star Traveller - Incl Hydroid Remix-(TSU6058) Vinyl
Year: 2005
Tracks: 2
Slinkey
Year: 2004
Tracks: 2
Rock Your Body Rock
Year: 2004
Tracks: 3
Right of Way CD2
Year: 2004
Tracks: 6
Right of Way CD1
Year: 2004
Tracks: 14
Mix By DJ Oliver Volume1
Year: 2004
Tracks: 3
Live At Dance Valley
Year: 2002
Tracks: 1
Live
Year: 2002
Tracks: 1
Live At Innercity - Amsterdam Rai
Year: 1999
Tracks: 16
Solar Serenades
Year:
Tracks: 15
Otherwise known as System F, Ferry Corsten blush wine to excrescence in the late '90s as unitary of Europe's top trance DJs, highlighted by an anthem-filled appearance on Ministry of Sound's first Trance Nation album. Before attaining such acknowledgement, Corsten began his DJing at the early eld of 15, when he would spin at schoolhouse parties. By his late teens, he was perusal to be an electrical engineer, an dream that was presently eclipsed by his growing interestingness in electronic dance music. Soon he was getting sound gear to produce his have tracks and started releasing his music under monikers such as Moonman, Pulp Victim, Vera Cocha, Gouryella (with DJ Tiesto), and System F, highlighted by the winner of his single "Extinct of the Blue," which entered the U.K.'s Top 20. Yet his almost successful make is undoubtably his cartroad "Air," under the pretence of Albion, a data track that has been championed by many of the world's top DJs (including Paul Oakenfold and John Digweed on their Globose Underground albums) and has since been re-released in 2000 as Aura 2000 on Platipus with additional remixes by artists such as Oliver Lieb and Hybrid. Meanwhile, Corsten likewise won good deal of attention for his high profile remix of Art of Trance's graeco-Roman "Republic of Madagascar." And even though his appearance as the guest DJ on Ministry of Sound's anthem-filled Trance Nation debut wasn't the sort of well-composed plant one would require from an experient DJ such as Corsten, it did help impel his identify farther into his audience's consciousness.
Winehouse leaves rehab to apply for visa
Singer Amy Winehouse left the rehab clinic where she is being treated for a short time yesterday in order to apply for a US visa.
According to reports, Winehouse left her London clinic for a few hours to meet with officials at the US Embassy.
She was accompanied by her father Mitch and a nurse, as the terms of her treatment require her to remain under supervision at all times.
Winehouse sported her custom black beehive, which had not made an appearance in recent weeks, after the star cut her hair and bleached it blonde.
It is thought that Winehouse is seeking a US visa in order to travel to Los Angeles to perform at the Grammys on 10 February. She is nominated for six awards at the ceremony.
The singer's visa application will not be simple due to the fact that she was arrested and fined in Norway for possession of cannabis.
A spokesperson for Winehouse said: "The appointment at the US Embassy was made some time ago and was part of process for obtaining a visa. No decision has been made about the Grammys."
"Amy was accompanied by a nurse as the appointment was under supervision. She has not left rehab and remains under the care of the clinic."
According to reports, Winehouse left her London clinic for a few hours to meet with officials at the US Embassy.
She was accompanied by her father Mitch and a nurse, as the terms of her treatment require her to remain under supervision at all times.
Winehouse sported her custom black beehive, which had not made an appearance in recent weeks, after the star cut her hair and bleached it blonde.
It is thought that Winehouse is seeking a US visa in order to travel to Los Angeles to perform at the Grammys on 10 February. She is nominated for six awards at the ceremony.
The singer's visa application will not be simple due to the fact that she was arrested and fined in Norway for possession of cannabis.
A spokesperson for Winehouse said: "The appointment at the US Embassy was made some time ago and was part of process for obtaining a visa. No decision has been made about the Grammys."
"Amy was accompanied by a nurse as the appointment was under supervision. She has not left rehab and remains under the care of the clinic."
Kelsey Grammer Suffers Heart Attack In Hawaii
The star of television's 'Frasier', Kelsey Grammer, has been hospitalized in Hawaii after suffering a mild heart attack over the weekend his rep has confirmed.
A statement released on Monday (June 2) says the 53-year-old "experienced symptoms Saturday morning after paddle boarding with his wife Camille at their Hawaiian home. Grammer was immediately taken to an area hospital where it was determined that he had a mild heart attack."
The rep adds that the actor is "resting comfortably" and is expected to be released this week.
NEXT: Kim Cattrall To Star In New TV Series
Photo courtesy of NBC. Taken by Justin Lubin.
Madonna Plans Documentary Sequel
Madonna is reportedly set to mark her 50th birthday by releasing a sequel to her infamous Truth Or Dare documentary next year . The hitmaker will produce the documentary with filmmaker Alex Keshishian, who directed the controversial 1991 movie, to celebrate her continued success in the music industry. And the film will act as a reunion for Madonna - she has reportedly signed up most of the original production team for the new venture. Keshishian is set to film the superstar over three weeks as she goes about her day-to-day life in London, according Britain's The London Paper. A source tells the publication, "It's like an In Bed With Madonna but made for today. She leads an amazing, high-paced life now and Alex thought the time was right to do another documentary of her life and career." The original documentary followed the star as she embarked on her hit 1990 Blonde Ambition tour, and proved a hit with fans, grossing ?29 million (?14.5 million) at the global box office.
See Also
See Also
Keith Urban - Urban Wants Baby To Go On Tour
Country star KEITH URBAN is keen not to spend too much time away from his expectant wife NICOLE KIDMAN - he wants the actress to join him on tour after she gives birth to their first child.
The Hours actress is expecting her first-biological child with Urban in summer (08), and the singer would love the mother and tot to accompany him on the road.
However, Urban understands the strain of being a new mum may hamper his plans to have a family orientated tour bus.
Urban tells People.com, "I love having her (Kidman) with me when I tour, but at the same time, it's work. You don't want to ask too much of your family."
"We'll just have to see what works for us."
See Also
Albion Band
Artist: Albion Band
Genre(s):
Folk
Discography:
Morris On vs. Richard Thompson, Mattacks, Kirkpatrick, Dransfield and Shirley Collins (Remastered)
Year: 1972
Tracks: 12
Originally used as a name to course credit the musicians hired to accompany Shirley Collins in 1971, the Albion Band later became a chemical group in their possess right. Bass player Ashley Hutchings, wHO had antecedently founded and left both Fairport Convention and Steeleye Span, is the driving force-out behind this group. The members use acoustic and Fairport Convention's, but usually more typically English in character reference. They have existed as the Albion Band, the Albion Country Band, and the Albion Dance Band.
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